Laboratories for Biomolecular Engineering & Nanotechnology

Group Members

Xiaohua Huang

Office:		3213 The Emory Clinic, Building B

Telephone:		404-727-9611

Fax:		404-727-3567

E-mail:		xhuan25@emory.edu

Mailing Address:		101 Woodruff Circle, Suite 2007 Atlanta, GA 30322

CV/Resume:

Education l Research Summary l Publications l Fellowships l Honors & Awards

Education

Distinguished CCNE Fellow, Department of Biomedical Engineering, Emory University	Aug 2008 - present
Postdoctoral Fellow, School of Chemistry and Biochemistry, Georgia Institute of Technology	Oct 2006 - Aug 2008
Ph.D., Analytical Chemistry, Georgia Institute of Technology	May 2006
M.S., Physical Chemistry, Peking University, P. R. China	July 2001
B.S., Chemistry, Jilin University, P. R. China	July 1996

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Research Summary

Prior to coming to Emory/Georgia Tech, Dr. Huang received her B.S. in Chemistry from Jilin University (Changchun, P.R. China) in 1996 and M.S. in Physical Chemistry from Peking University (Beijing, P.R. China) in 2001. In 2002 she began graduate school at Georgia Tech where she received her Ph.D. in Analytical Chemistry in 2006 and continued as a postdoctoral fellow under the guidance of Prof. Mostafa A. El-Sayed. Her dissertation was entitled, "Gold Nanoparticles Used in Cancer Cell Diagnostics, Selective Photothermal Therapy and Catalysis of NADH Oxidation Reaction". In this project, she synthesized, characterized and bioconjugated gold nanoparticles in different sizes and shapes. Using these functionalized gold nanoparticles, especially colloidal gold nanospheres and nanorods, she developed optical methods for cancer diagnosis using dark field light scattering imaging, surface plasmon resonance absorption spectroscopy and surface enhanced Raman scattering. She also developed selective photothermal therapy of cancer using antibody conjugated gold nanospheres in combination with a visible argon ion laser and gold nanorods in combination with a near infrared diode laser.

Her current research is medical applications of novel nanoparticles with focuses on two areas: one is to develop colloidal gold nanoparticles (including nanorods) for tumor therapeutic applications and the other is to develop advanced quantum dots and related nanoparticles for intraoperative cancer imaging. Colloidal gold nanoparticles have demonstrated great potential for cancer therapeutic applications due to the unique photothermal properties, as shown by in vitro and preliminary in vivo studies. Comprehensive studies on some critical issues such as the bio-distribution, toxicity, tumor accumulation and photothermal efficiency of gold nanoparticles especially gold nanorods in different aspect ratios will be conducted before their uses in clinic trials. In addition, she will devote her efforts in developing other types of advanced nanoparticles such as quantum dots and iron oxide for cancer imaging and their translation to practical applications

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Publications and Presentations

Publications:

Arianna Biesso, Wei Qian, Xiaohua Huang, Mostafa El-Sayed. “Gold Nanoparticles Surface Plasmon Field effects on the Proton Pump Process of the Bacteriorhodopsin Photosynthesis”. J. Am. Chem. Soc., accepted.
Xiaohua Huang, Svetlana Neretina, Mostafa A. El-Sayed. "Gold nanorods: from synthesis and properties to biological and biomedical applications." Advanced Materials, invited review, in press.
Prashant K. Jain, Xiaohua Huang, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Noble metals on the nanoscale: optical and photothermal properties and applications in imaging, sensing, biology, and medicine". Accounts of Chemical Research, invited review, 2008, 41(12), 1578-1586.
Erin B. Dickerson, Erik C. Dreaden, Xiaohua Huang, Hunghao Chu, Sujatha Pushpanketh, John F. McDonald and Mostafa A. El-Sayed. "Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of HSC-3 tumors in mice". Cancer Letters, 2008, 269, 57-66.
Xiaohua Huang, Prashant K. Jain, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Plasmonic photothermal therapy using gold nanoparticles". Lasers in Medical Science, invited review, 2008, 23(3), 217-228..
Ivan H. El-Sayed, Xiaohua Huang, Mostafa A. El-Sayed, "Multicolorimetric plasmonic gold nanoparticles for optical detection of oral squamous carcinoma," Oral Oncology, 2007, 2, 121-121 (2007).
Xiaohua Huang, Wei Qian, Ivan H. El-Sayed and Mostafa A. El-Sayed. "The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy". Lasers in Surgery and Medicine, 2007, 39, 747-753.
Ivan H. El-Sayed, Xiaohua Huang, Fima Macheret and Randall Kramer. "Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer". Technology in Cancer Research and Treatment, 2007, 6(5), 403-412.
Xiaohua Huang, Prashant K. Jain, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy". Nanomedicine, invited review, 2007, 2(5), 681-693.
Adegboyega K. Oyelere, Po C. Chen, Xiaohua Huang, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Peptide conjugated gold nanorods for nuclear targeting". Bioconjugate Chemistry, 2007, 18, 1490-1497.
Xiaohua Huang, Ivan H. El-Sayed, Wei Qian and Mostafa A. El-Sayed. "Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp and polarized surface raman spectra: a potential cancer diagnostic marker". Nano Letters, 2007, 7(6), 1591-1597.
Prashant K. Jain, Xiaohua Huang, Ivan H. El-Sayed, Mostafa A. El-Sayed. "Review of some surface plasmon resonance-enhanced properties of noble metal nanoparticles and their applications to biosystems". Plasmonics, invited review, 2007, 2, 107-118.
Xiaohua Huang, Ivan H. El-Sayed, Wei Qian and Mostafa A. El-Sayed. "Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods". Journal of the American Chemical Society, 2006, 128 (6), 2115-2120. Citation: 244.
Xiaohua Huang, Prashant K. Jain, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Determination of the minimum temperature required for selective photothermal destruction of cancer cells using immunotargeted gold nanoparticles". Photochemistry and Photobiology, 2006, 82 (2), 412-417.
Ivan H. El-Sayed, Xiaohua Huang, Mostafa A. El-Sayed. "Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles". Cancer Letters, 2006, 239 (1), 129-135.
Xiaohua Huang, Ivan H. El-Sayed, Mostafa A. El-Sayed. "The use of surface enhanced absorption, scattering and catalytic properties of gold nanoparticles in some bio- and biomedicine applications". Proceedings of SPIE-The International Society for Optical Engineering, 2005, 5929, 94-103.
Ivan H. El-Sayed, Xiaohua Huang, Mostafa A. El-Sayed. "Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer". Nano Letters, 2005, 5 (5), 829-834. Citation: 160.
Xiaohua Huang, Ivan H. El-Sayed, Xiaobing Yi, Mostafa A. El-Sayed. "Gold nanoparticles: catalyst for the oxidation of NADH to NAD+". Journal of Photochemistry and Photobiology B: Biology, 2005, 81, 76-83.
Yuhua Huang, Jie Fu, David J. Hagan, Shin-Tson Wu, Xiaohua Huang, Mostafa A. El-Sayed and Shin-Tson Wu. "Ultroviolet protection using intensity-dependent spectral shift in bacteriorhodopsin". IEEE Journal of Selected Topics in Quantum Electronics, 2005, 11(4), 902-905.
Xiaohua Huang, Huizhong Huang, Deen Jiang, Biying Zhao. "Investigation of the structures of gamma-Al2O3-supported MgO by Surface Extended Energy Loss Fine Structure". Journal of Physical Chemistry A, 2002, 106, 2815-2820.
Xiaohua Huang, Huizhong Huang, Deen Jiang, Biying Zhao. "Investigation of the dispersion of MgO onto gamma-Al2O3 by SEELFS". Modern Instruments (in Chinese), 2001, 1, 39-41.
Xiaohua Huang, Huizhong Huang, Nianzu Wu, Ruisheng Hu, Tao Zhu, Zhongfan Liu. "Investigation of structure and chemical states of self-assembled Au nanoscale particles by angle-resolved x-ray photoelectron spectroscopy". Surface Science, 2000, 459, 183-190.
Xiaohua Huang, Huizhong Huang, Deen Jiang, Biying Zhao. "Investigation of the structures of Mg-Al mixed oxides by SEELFS". Acta Chimica Sinica (in Chinese), 2000, 58, 909-911.
Ruisheng Hu, Tao Zhu, Zhongfan Liu, Xiaohua Huang, Huizhong Huang. "Covalent attachment of gold nanoparticles onto the thiol-terminated surface through Au-S Bonding". Acta Physical-Chimica Sinica (in Chinese), 1999, 15, 961-964

Presentations:

Mostafa A. El-Sayed, Prashant Jain, Xiaohua Huang. "Plasmonic field imaging and coupling in biological and biomedical systems", 235th ACS National Meeting, New Orleans, LA, April 2008.
Xiaohua Huang, Ivan H. El-Sayed, Mostafa A. El-Sayed, Po C. Chen, Adegboyega K. Oyelere. "Molecular cancer targeting and diagnostics using plasmonic gold nanoparticles". Second Annual AACR International Conference on "Molecular Diagnostics in Cancer Therapeutic Development: Maximizing Opportunities for Personalized Treatment", Atlanta, GA, September 2007.
Xiaohua Huang, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Applications of gold nanoparticles in cancer cell diagnostics and therapy". 234th ACS National Meeting, Boston, MA, August 2007.
Xiaohua Huang. "Gold Nanoparticles Used in Cancer Cell Diagnostics and Therapy". Georgia Tech Square Symposium, Atlanta, GA, March 2007.
Xiaohua Huang, Ivan H. El-Sayed, Wei Qian and Mostafa A. El-Sayed. "Cancer cell diagnostics and photothermal therapy by using gold nanospheres and nanorods". 232nd ACS National Meeting, San Francisco, CA, September 2006.
Xiaohua Huang, Ivan H. El-Sayed and Mostafa A. El-Sayed. "Cancer cell diagnostics and therapy using gold nanoparticles". 231st ACS National Meeting, Atlanta, GA, March 2006.
Deen Jiang, Biying Zhao, Xiaohua Huang, Huizhong Huang, Guangcheng Pan, Guopeng Ran and Enze Min. "Comparison of gamma-alumina supported MgO and bulk mixed Mg-Al oxide as solid base catalysts". 228th ACS National Meeting, Philadelphia, PA, August 2004.
Xiaohua Huang, Wenyu Huang, Laurie Sanii and Mostafa A. El-Sayed. "The absorption and fluorescence spectroscopy of bacteriorhodopsin in bicelle crystals". 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, November 2003.
Xiaohua Huang, Huizhong Huang, Nianzu Wu. "Investigation of the structure of gamma-Al2O3-supported MgO by SEELFS". Asia - Pacific Surface and Interface Analysis Conference, Beijing, China, October 2000.
Xiaohua Huang, Huizhong Huang, Nianzu Wu. "Investigation of the coating of self-assembled gold nanaparticle". The 9th National Conference of Surface Physics, Hangzhou, China, November 1999

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Fellowships

Emory-Georgia Tech Center of Cancer Nanotechnology Excellence Distinguished Fellowship, 2008-present

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Honors and Awards

AACR-Women in Cancer Research Brigid G. Leventhal Scholar in Cancer Research, 2007

AACR-Aflac, Inc. Travel Award, Second Annual AACR International Conference on "Molecular Diagnostics in Cancer Therapeutic Development: Maximizing Opportunities for Personalized Treatment", Atlanta, September 2007

National Analytical Technique Society Award, First Place, P. R. China, 2002

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